To elucidate this question, we investigate cell type-specific nuclear architecture organized by nuclear structural proteins, such as nuclear pores or nuclear lamins.
Aging is one of the most critical risk factors for neurological and psychiatric diseases. However, the biological links between physiological brain aging and pathological development are still largely unknown. Our lab aims at seeking a link between the fundamental mechanism underlying the long-term maintenance of neural function and effects of ageing on that, by focusing on cell-type specific nuclear architecture.
Adult neural stem cells are retained in the specific brain regions such as the hippocampus and provide structural and functional plasticity in the adult brains. However, their neurogenic capability is lost during aging. We study how adult neural stem cells are aged and if we could rejuvenate them.
With the support, we will explore roles of nuclear RNAs in the long-term maintenance of neural epigenome. Stay tune!
At MPZ-PM, the Toda lab will explore epigenetic mechanisms underlying the long-term maintenance of neural epigenome and their connections to nuclear biophysics
Tomo is a Professor at FAU and a group leader at DZNE in Dresden, Germany. His research focus is to understand the roles of nuclear architecture in neural development/evolution, maintenance and brain aging. Tomo completed his PhD in the University of Tokyo and his postdoc in Rusty Gage’s lab at the Salk Institute. The Toda lab has been established based on the support from the ERC starting grant in 2019.
Sara completed her PhD at the Kempermann Lab @CRTD. After the trainings in in vivo imaging, she has joined the Toda lab with strong interests in epigenetic aging and its causality in cognition.
Josue has joined the Toda lab as a computational postoc since 2023. His hobby is research!
Anne is a research technician and a specialist of animal experiments. She likes sushi and tea.
Abhi is the first PhD student from DIPP program. His focus is on the role of nuclear architecture in neural plasticity. He received her B. tech and M..tech from Indian Institute of Technology Kanpur, India in bioengineering and developmental biology. He likes to learn new technology and enjoy bouldering in Dresden.
Clara is a PhD student through the DIPP program, and interested in how environmental factors modulate cellular plasticity through nuclear architecture.
Ludovica is a PhD student from Italy. She is interested in how nuclear architecture dictates the development and maintenance of specific neural identity.
Diana obtained MSc from TU Dresden. After additional training at UKD, Diana comes back to the Toda lab as a research technician. We are so happy that she is back!
Julia has been trained as a veterinarian and biochemist. Upon the move of the lab to FAU, Julia has join the lab as a research technician.
Kristin is an administrative assistant, and help to take care of grants and HR related issues in the lab.
Jana is an administrative assistant, and take care of difficult German regulation and logistics for the lab.
We are always looking for highly motivated and creative students. Students interested in a master’s project with a focus on epigenetics, neurobiology and brain aging are encouraged to contact Tomo or apply through IMPRS-PM.
We are also supporting fellowship applications of outstanding postdoctoral researchers who wish to join our lab.
International students and researchers are particularly encouraged to get in touch. In case you are interested in working with us please contact Tomo.
Now works at the industry
Now Coordinator at Bonn University
Now PhD student @ CRTD TU Dresden
Zocher S and Toda T
Bedrosian, TA*, Houtman J*, Eguiguren JS, Ghassemzadeh, S, Rund N, Novaresi. NM, Hu L, Parylak S, Denli AM, Moore RM, Namba T, Gage FH, and Toda T.
EMBO Journal (2021): e105819. doi: 10.15252/embj.2020105819
Soni A , Klütsch D, Hu X , Houtman J, Rund N, McCloskey A , Mertens J, Schafer ST, Amin H*, Toda T* (*Co-corresponding)
Cells, ;10(8):1894. doi: 10.3390/cells10081894 (2021).
Schlachetzki J., Toda T. *, and Mertens J. * (Co-corresponding).
Experimental Gerontology, 133:110876, (2020).
Toda T, Parylak S, Linker SB & Gage FH.
Molecular Psychiatry, 24;67-87, (2019)
Kuhn HG*, Toda T* (*Equal contribution), and Fred H. Gage FH.
J. Neuroscience, 38, 10401-10410 (2018)
Selected as a cover picture
Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW & Gage FH.
Cell Stem Cell, 21, 5, 618-634 (2017)
Spotlight by: Nuclear Pore Protein Meets Transcription Factor in Neural Fate, Neuron, 96, 259-261 (2017) Taro Kitazawa, Filippo M. Rijli
Toda T, Shinmyo Y, Duong TAD, Masuda K & Kawasaki H.
Scientific Reports, 6:29578. (2016)
Hoshiba Y, Toda T, Ebisu H, Wakimoto M, Yanagi S & Kawasaki H.
J. Neuroscience 36, 5775-5784 (2016)
Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves T, Toda T, Kim Y, Winkler J, Yao J, Hetzer M & Gage FH.
Cell Stem Cell, 17, 705-718 (2015)
Toda T, Homma D, Tokuoka H, Hayakawa I, Sugimoto Y, Ichinose H & Kawasaki H. .
Developmental Cell, 27, 32-46. (2013)
Preview by: The birth of Barrels, Developmental Cell, 27, 3-4 (2013)
Gaspar P & Erzurumulu R.
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